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NSC 145366
CAS No. 1052515-37-3
NSC 145366 ( NSC145366 )
产品货号. M10250 CAS No. 1052515-37-3
NSC 145366 是一种新型变构 Hsp90 CTD（C 末端结构域）抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
|
| 50MG | ￥16038 | 有现货 |
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| 100MG | ￥20250 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称NSC 145366
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述NSC 145366 是一种新型变构 Hsp90 CTD（C 末端结构域）抑制剂。
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产品描述NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM; increases Hsp90 oligomerization resulting in allosteric inhibition of NTD ATPase activity (IC50=119 uM), but does not compete with NTD or CTD-ATP binding; causes selective client protein downregulation including AR and BRCA1 but without a heat shock response in LNCaP prostate tumor cells.
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体外实验——
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体内实验——
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同义词NSC145366
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点HSP
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受体HSP
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研究领域——
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适应症——
化学信息
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CAS Number1052515-37-3
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分子量635.371
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分子式C37H63ClN2O4
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(C1=CC=C(OCC(O)CNC(C)(C)CC(C)(C)C)C=C1)(C2=CC=C(OCC(O)CNC(C)(C)CC(C)(C)C)C=C2)C.[H]Cl.[H]Cl
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化学全称1-[4-[2-[4-[2-hydroxy-3-(2,4,4-trimethylpentan-2-ylamino)propoxy]phenyl]propan-2-yl]phenoxy]-3-(2,4,4-trimethylpentan-2-ylamino)propan-2-ol hydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Thomas FM, et al. SLAS Discov. 2017 Jul;22(6):706-719.
2. Goode KM, et al. Biochim Biophys Acta. 2017 Aug;1861(8):1992-2006.
